It got one of my computers, running Trendmicro antivirus/antispyware and ZoneAlarm...all behind a secured network. The only thing I found to get rid of it was Windows Defender, which came on my new laptop and wasn't on my old desktop. I now run Defender every morning at 3AM just to be sure.
Lucky20, Defender isn't the same as the malicious software removal tool that Microsoft puts out with security updates.
LinkNote: Defender no longer works with operating systems Windows 2000 and older (95/98).